Modeling polyelectrolyte translocation through protein channels

We will present results from Brownian Dynamics simulations of translocation of polyelectrolyte chains through alpha-hemolysin and MspA protein channels. Comparisons will be made between these two pores in terms of the various characteristics of translocation events. Specifically, we will discuss the distribution functions of blocked ionic current and translocation time. The critical roles played by the charge decorations and the geometries of these two protein pores will be presented. The sequence of the polymer will also be addressed.