Carbogen Enhanced Femto Oximetry Breast Cancer Diagnosis Method with High Specificity

As large malignant tumors are oxygen deficient (hypoxic), cancer could be diagnosed \textit{in vivo} and online, by non-invasive measurement of oxygen difference between tumor and adjacent tissue. Computer simulations of noninvasive diagnosis by Femto Oximetry (FO) of hypoxia in 1 cm tumor in 10 cm breast shows that background $\gamma $'s from non hypoxic tissue will mask hypoxia. To amplify the hypoxic-to-normal O difference, air breathing will be replaced with carbogen (O$_{2}$ 95{\%}, CO$_{2}$ 5{\%}) using vasco-constrictive property whereby carbogen breathing increases O in normal tissue, while not in malignant hypoxic tumors. 90{\%} hypoxia will be detectable by FO with specificity 99{\%}. Our method will be tested on R3230 tumors in Fischer rats at UCI.