Magnetite-Alginate-AOT nanoparticles based drug delivery platform

POSTER

Abstract

Iron oxide having the magnetite structure is a widely used biomaterial, having applications ranging from cell separation and drug delivery to hyperthermia. In order to increase the efficacy of drug treatments, magnetite nanoparticles can be incorporated into a composite system with a surfactant-polymer nanoparticle, which can act as a platform for sustained and enhanced cellular delivery of water-soluble molecules. Here we report a composite formulation based on magnetite and Alginate-aerosol OT (AOT) nanoparticles formulated using an emulsion-cross-linking process loaded with Rhodamine 6G [1]. We prepared two set of nanoparticles by using Ca$^{2+}$ or Fe$^{2+}$ to cross-link the alginate polymer. Additionally, we added $\sim $8 nm diameter Fe$_{3}$O$_{4}$ magnetic nanoparticles prepared by a soft chemical method to these alginate-AOT nanoparticles. The resulting composites were superparamagnetic at room temperature, with a saturation magnetization of approximately 0.006 emu/g of solution. We will present detailed studies on the structural and magnetic properties of these samples. We will also discuss HPLC measurements on Rhodamine uploading in these composites. [1] M.D.Chavanpatil, Pharmaceutical Research, vol.24, (2007) 803.

Authors

  • R. Regmi

    Department of Physics and Astronomy, Wayne State University

  • C. Sudakar

    Wayne State University, Department of Physics and Astronomy, Wayne State University, Detroit, MI 48201, Wayne State University, Detroit, MI, Dept. of Physics and Astronomy, Wayne State University, Detroit, MI 48201 USA., Department of Physics and Astronomy, Wayne State University, Department of Physics and Astronomy Wayne State University

  • A. Dixit

    Department of Physics and Astronomy, Wayne State University

  • R. Naik

    Wayne State University, Department of Physics and Astronomy, Wayne State University, Detroit, MI 48201, Wayne State University, Detroit, MI, Dept. of Physics and Astronomy, Wayne State University, Detroit, MI 48201 USA., Department of Physics and Astronomy, Wayne State University, Department of Physics and Astronomy Wayne State University

  • G. Lawes

    Wayne State University, Department of Physics and Astronomy, Wayne State University, Detroit, MI 48201, Dept. of Physics and Astronomy, Wayne State University, Detroit, MI 48201 USA., Department of Physics and Astronomy, Wayne State University, Department of Physics and Astronomy Wayne State University

  • U. Toti

    College of Pharmacy, University of Minnesota

  • J. Panyam

    College of Pharmacy, University of Minnesota

  • P.P. Vaishnava

    Kettering University