Control of Polymer Translocation with External Forcing

We investigate the dynamics of driven polymer translocation through a nanopore using two-dimensional Langevin dynamics simulations within the bead-spring model. A pulling force $F$ is exerted on the first monomer whilst there is an opposing force $F_E$ in the pore. For this setup, we calculate the distribution of translocation time $\tau$, which is defined as the time for the polymer to traverse from one side of the membrane to the other, and the waiting time $t_W$, which is defined as the time between the translocations of the $i$th and the $(i+1)$th bead. As our main result, we characterize the fluctuations and the positions of the beads along the direction of $F$ with respect to the position of the segments in the nanopore, and with respect to the position of the pore. Implications of these results to actual sequencing experiments are discussed.