Optimizing coherence domain imaging system for biomedical imaging

Holographic optical coherence imaging (OCI) system has shown promise in record full-frame depth-resolved images in tumor tissues, allowing real-time video display. Normally a holographic OCI system consists of a low coherence interferometry, a dynamic coherent filter and a CCD camera for image record and display. The key component in the system is photorefractive multiple quantum wells (PRQW) devices that act as the coherence filter passing full-frame image bearing light while rejecting the scattered background. Holographic OCI system is optimized by considering adaptive capabilities, speckle suppression and higher diffraction efficiency of the devices. Both AlGaAs/GaAs and InGaAs/GaAs devices have been examined at different working wavelengths based on degenerate four-wave mixing and non-degenerate four-wave mixing.