Numerical modeling on the effect of plasma-produced species on immune cells behavior

Recently, it has been found that low-temperature plasma can induce immunogenic cell death (ICD) by causing cancer cells to release damage-associated molecular patterns. Although the mechanism has not fully understood, it is suggested that the plasma-induced ICD is a result of plasma produced reactive oxygen nitrogen species (RONS). Since the collective behavior of immune cells play a critical role in ICD, it is important to examine the influence of RONS the immune cell dynamics. In this work, we developed two-dimensional agent model to simulate neutrophils dynamics, that is, migration and phagocytosis under the influence of plasma irradiation. With increasing plasma-derived hydrogen peroxide, the concentration of neutrophils migrating from blood vessels into tissues increases. As a result, neutrophils efficiently reach the target (cancer cells) and phagocyte them.