DNA Origami Motifs for Fast Localized Communication

Over the past decades, dynamic DNA origami structures have emerged as promising candidates for nanoscale signal and cargo transport. Despite relatively fast diffusion rates, these structures face limitations in communication speed due to the reaction-limited nature of strand exchange mechanisms used for signal and cargo transfer. In this study, we explore how spatial confinement can expedite communication among DNA walkers and compare two potential mechanisms: one that constrains molecular motion to pseudo-rotational dynamics, and another that confines it to pseudo-linear dynamics. Using stochastic theories, we suggest that a combination of both mechanisms yields the highest velocity enhancement. This study offers novel insights into leveraging structural motifs to optimize signal propagation rates, with implications for sensing and computing applications in reaction-diffusion systems.