Nuclear Physics of DNA: Evidence for Mutations of Free DNA Nucleotides in Nuclear Inelastic Scattering with 14 MeV Neutrons and Applications
ORAL
Abstract
First experimental study of interactions between \textit{nuclear} particles whose $\lambda _{DeBroglie} \quad \sim $ 10$^{-15}$ m and \textit{nano}particles (r $\sim $ 10$^{-9}$ m) of free DNA nucleotides is presented. Each collision knocks out 1 atom and creates mutated DNA or DNA breakup. Targets: dAdenosine (C$_{10}$O$_{6}$N$_{5}$H$_{13}$P), dCytodine (C$_{9}$O$_{7}$N$_{3}$H$_{14}$P) and dThymidine (C$_{10}$O$_{8}$N$_{2}$H$_{15}$), differing by 1 O or 1 C atom. We measured high-resolution prompt $\gamma $ spectra of $\sim $ 10$^{7}$ inelastic scatterings of 14 MeV n's: n+O $\rightarrow$ O+n'+ $\gamma $ (6.128 MeV) and n+C $\rightarrow$ C + n' + $\gamma $ (4.44 MeV). C or O ejection from 3 DNA's should manifest itself as 3 (2) $\gamma $ peaks corresponding to 6, 7, 8 O (9, 10 C). We observed 3 O $\gamma $ peaks containing 8,526$\pm $400, 10,495$\pm $ 402, 11,448 $\pm $405 each; and 2 C peaks, as expected; and decoded stoichiometry of 3 DNA's with 3-5 $\sigma $ in 30', signal/background $\sim $2{\%}. Applications of \textit{femto atometry} to genometrics, genetic engineering and noninvasive cancer diagnostics will be presented{\ldots} (maglich@calseco.com)
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Authors
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Bogdan C. Maglich
CALSEC California Science \& Engineering Corp.
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Luz Marie Aquino
CALSEC California Science \& Engineering Corp.
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Chris Druey
CALSEC California Science \& Engineering Corp.
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Anna Z. Radovic
UCI