Physiological Cerebrospinal Fluid Flow Tomographic PIV Measurements

This study employs tomographic particle image velocimetry (tomo-PIV) to examine pulsatile cerebrospinal fluid (CSF) flow within a flexible in vitro spinal canal model made from polydimethylsiloxane (PDMS). Experimental studies that can capture complex pulsatile flow patterns, particularly in anatomically accurate and compliant models, are essential for enhancing our understanding of CSF flow physics. This study presents experimental results focused on the thoracic region. Measurements were performed at three Reynolds numbers and three Womersley numbers within the physiological ranges shown in the literature (Re: 40-120, Wo: 4-6). High-resolution, time-resolved volumetric velocity fields provide detailed insights into flow structures during the pulsatile cycle. Coherent vortical structures were identified and quantified with the Q-criterion and λ-2 methods, confirming the formation and evolution of vortices during flow acceleration and deceleration. The experimental findings provide valuable information for improving the understanding of pulsatile CSF dynamics in flexible models and guiding future physiological modeling studies.