Enhanced Hemodynamics in Patient-Specific Cerebral Aneurysms Due to the Impact of Body Movement: An In-Vitro Study

We aim to understand how human body movement impacts the hemodynamics of cerebral aneurysms due to the physical motion of the vessel wall, beyond typical physiological responses. We first employ a high-speed camera to capture human head movement. Subsequently, we perform in-vitro hemodynamics measurements in a cerebral aneurysm phantom model using a high-speed PIV system on a six-degree-of-freedom motion simulation platform. Three different Patient-specific cerebral aneurysm models are utilized, and different inlet blood flow conditions are tested. We explore and verify the effects of three types of body movements: Simple Harmonic Motion, Single Jump, and Continuous Jumping Motion. In the control group, we measure hemodynamics when the motion simulation platform is at rest. In the treatment groups, hemodynamics measurement and body movement replaying are simultaneously conducted under identical inlet flow conditions in both simplified and patient-specific geometries. We observed clear differences in flow field and wall shear stress between these groups. This study suggests that, besides physiological responses, body movement also physically contributes to intense hemodynamic changes that need to be considered during the design and verification of any drug or biomedical device.