Transport and lymphatic uptake of biotherapeutics after subcutaneous injection

The subcutaneous injection has emerged as a common approach for self-administration of biotherapeutics due to patient comfort and cost-effectiveness. Here we aim to find drug distribution in the tissue and lymphatic uptake after subcutaneous injection. A high-fidelity computational model of poroelastic tissue is developed to find the biomechanical response of the tissue to injection. The effects of layered tissue properties with primary layers, including epidermis, dermis, subcutaneous, and muscle layers, on tissue biomechanical response and drug transport are discussed. The role of secondary tissue elements like the deep fascia layer and the network of septa fibers inside the SQ tissue is investigated. The process of plume formation, interstitial pressure, and drug transport is explored. Finally, the computational model is validated against experimental studies available in the literature.