Title: Predictions of microvascular leak from an anatomically correct mouse GI tract

Abstract:

Prior research resulted in the discovery of a novel RX protein proven to cause cell death in injected mice via hyper vasoconstriction. This project seeks to lay further groundwork for trauma research and ultimately a solution to the failure of the major organs in humans after experiencing major trauma on the battlefield or otherwise. This was achieved by creating a CAD-modeled section of the microvasculature in the GI tract of a mouse. The necessary data and images were previously attained through Electron Scanning Microscopy (ESM) analysis of the intestinal mucosa. Based on acquired blood flow and pressure data as well as measured lumen diameter response data to the RX protein, an average base pressure, flow rate and scale were chosen. This idealized model was compared to simulations in which the base values were construed by the vasoconstriction response of both venules and arterioles and an induced jejunal microvascular leak​. Then, graphical techniques related to pressure and blood flow changes provide further data for continued research in this field.