Enhanced hemodynamics in cerebral aneurysm due to the impact of body movement, an in-vitro study

We aim to understand how human body movement may impact the hemodynamics of cerebral aneurysms due to the physical motion of the vessel wall, beyond typical physiological responses. We first employ a motion collection system to capture the human head movement. We then implement and verify a six-degree-of-freedom motion simulation platform to replay the human head motion. Lastly, and most importantly, we perform an in-vitro hemodynamics measurement in a cerebral aneurysm phantom model, using a high-speed PIV system on this motion simulation platform. Both simplified and patient-specific cerebral aneurysm models are utilized, and different inlet blood flow conditions are tested during this study. In the control group, we measure hemodynamics when the motion simulation platform is at rest. In the treatment group, the hemodynamics measurement and body movement replaying are simultaneously conducted, with identical inlet flow conditions. We evidenced clear differences in hemodynamics in these two groups. This study suggests that, besides physiological response, body movement also physically contributes to the intense hemodynamic changes that need to be considered during any drug or biomedical device design and verification.