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Computational study of inertial migration of prolate particles in a straight rectangular channel

ORAL

Abstract

Inertial migration of spherical particles has been investigated extensively using experiments, theory, and computational modeling. Yet, a systematic investigation of the effect of particle shape on inertial migration is still lacking. Herein, we numerically mapped the migration dynamics of a prolate particle in a straight rectangular microchannel using smoothed particles hydrodynamics (SPH), at moderate Reynolds number flows. After validations, we applied our model to 2:1 and 3:1 shape aspect ratio particles at multiple confinement ratios. Their effects on the final focusing position, rotational behavior, and transitional dynamics were studied. In addition to the commonly reported tumbling motion, for the first time, we identified a new logrolling behavior of a prolate ellipsoidal particle in the confined channel. This new behavior occurs when the confinement ratio is above a threshold value of K = 0.72. Our microfluidic experiments using cell aggregates with similar shape aspect ratio and confinement ratio confirmed this new predicted logrolling motion. Our findings are especially relevant to the applications where particle shape and alignment are used for sorting and analysis, such as the shape-based enrichment of microalgae, bacteria, and chromosomes.

Publication: "Computational study of inertial migration of prolate particles in a straight rectangular channel", submitted and towards publication in Physics of Fluids

Presenters

  • Giuseppe Lauricella

    Double degree MS student at UIC and Politecnico di Milano (Milan, Italy) - Research Assistant in Computational Inertial Microfluidics

Authors

  • Giuseppe Lauricella

    Double degree MS student at UIC and Politecnico di Milano (Milan, Italy) - Research Assistant in Computational Inertial Microfluidics

  • Ian Papautsky

    Department of Biomedical Engineering, University of Illinois at Chicago, Co-Director, NSF Center for Advanced Design & Manufacturing of Integrated Microfluidics, Richard and Loan Hill Professor of Bioengineering Co-Director, NSF Center for Advanced Design & Manufacturing of Integrated Microfluidics

  • Jian Zhou

    Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, PhD, Electrical Engineering University of Cincinnati, 2012

  • Zhangli Peng

    Department of Biomedical Engineering, Center for Bioinformatics and Quantitative Biology, University of Illinois at Chicago, Assistant Professor Center for Bioinformatics and Quantitative Biology Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago