Integration of Catheter Based Hemodynamic Data with 3D Rotational Angiography for Computational Hemodynamics Modeling of Congenital Heart Disease.

3D Rotational Angiography (3DRA) is standard-of-care for congenital heart disease (CHD). However, 3DRA is not commonly the imaging of choice for integration with CFD analysis, unlike Computed Tomography or Magnetic Resonance imaging. 3DRA Imaging has many advantages over other imaging modalities such as higher resolution, no additional increase in radiation, and availability of active hemodynamic information. These can be advantageous when paired with CFD to enable improved CHD treatment by providing physicians visualizations of how blood flows throughout the vasculature of interest pre- and post-surgery. Physiologically consistent flow visualization requires systematic integration of catheter hemodynamic data with 3DRA imaging. In this study, we present 3D in silico cardiovascular CFD modeling approach to demonstrate the use of 3DRA imaging paired with catheter derived hemodynamic data. Simulation case studies will be discussed for four cases involving different anatomies, physiologies, and flow states. Flow ratios and distributions based on simulation results will be used to illustrate how closely these results match with the hemodynamic information assigned for each model from clinical measurements.