Evaluating the effect of varying inflow waveform conditions on hemodynamics in a patient specific cerebral aneurysm using 4D PIV

Accurately accessing the risk and rupture of a cerebral aneurysm is critical in order to evaluate the treatment options for patients harboring an intracranial aneurysm (IA). Hemodynamic factors such as wall shear stress (WSS) and oscillatory shear stress (OSS) are known to contribute to the progression of IAs. However, current studies, across all modalities, assume fixed inflow conditions and fail to consider the inherently transient nature of the flow in the aneurysm as the patient moves or exercises. In this work, we consider how varying in-flow conditions, including flow magnitude and heart rate, affects the hemodynamics in and around an IA. We use a polydimethylsiloxane (PDMS) model of a patient specific spherical right middle cerebral artery (R MCA) bifurcation aneurysm in a volumetric particle image velocimetry (PIV) study. Moreover, we evaluate the sensitivity of key factors including WSS and OSI to the transient inflow conditions.