Augment high-resolution-impedance-manometry using biophysical analysis and model

ORAL

Abstract

Using biophysical analysis, we first evolved high-resolution-impedance-manometry (HRIM) into a 4 dimensional construct that allows one to assess the relationship between esophageal wall shape and bolus transit during swallowing. This provides 3D lumen morphology concurrent with pressure and signifies how the bolus transit pattern is modulated by contraction waves. It also extends previous bolus-retention analysis based on impedance change to direct visualization of evolution of bolus volume. Related results from normal and abnormal cases were compared. Furthermore, using our previously developed constraint-based immersed-boundary method, we developed a bio-mechanical model that augments the morphology data of HRIM. This augmented model enabled us to predict esophageal wall properties and flow characteristics. Results on the flow field and wall tension based on this augmented model were presented and discussed.

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Presenters

  • Wenjun Kou

    Feinberg School of Medicine, Northwestern University, Northwestern University

Authors

  • Wenjun Kou

    Feinberg School of Medicine, Northwestern University, Northwestern University

  • Shashank Acharya

    Dept. of Mechanical Engineering, Northwestern University, Mechanical Engineering, Northwestern University, Northwestern University

  • Peter J. Kahrilas

    Dept. of Mechanical Engineering, Northwestern University, Feinberg School of Medicine, Northwestern University, Northwestern University

  • Neelesh Ashok Patankar

    Department of Mechanical Engineering, Northwestern University, Dept. of Mechanical Engineering, Northwestern University, Mechanical Engineering, Northwestern University, Theoretical and Applied Mechanics, Northwestern University, Northwestern University, Northwestern Univ

  • John Erik Pandolfino

    Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Feinberg School of Medicine, Northwestern University, Northwestern University