To biofilm or not to biofilm: the autoinducer-yield parameter for determining biofilm formation

Selena Chiu; Abdul Qadeer Rehan; Abdul Qadeer Rehan; Abdul Qadeer Rehan; Abdul Qadeer Rehan

To biofilm or not to biofilm: the autoinducer-yield parameter for determining biofilm formation

ORAL

Abstract

Bacteria form biofilms in a host of organic environments, from soil to the mammalian gut. While biofilms assist in remediating soil contaminants, they also cause infection, from chronic lung infections in cystic fibrosis patients to industrial biofouling. It is, thus, vital to understand factors regulating the extent of biofilm formation to develop potential treatments for better human and environmental health. Unfortunately, little is known about the transition of free-swimming planktonic bacteria to sedentary biofilms in these environments. Here, we simulate bacterial behavior in heterogenous media to investigate the competition between bacterial dispersal, governed by chemotaxis, and biofilm formation, triggered by autoinducer accumulation. My work in this project focuses on characterizing the competition between bacterial cell yield and autoinducer secretion in determining the extent of biofilm formation. By simulating bacterial activity while varying cell yield and autoinducer secretion, I determined an autoinducer-yield parameter quantitatively predicts the extent of biofilm formation given the rate of cell yield and autoinducer secretion. Simulation results demonstrate a critical value at which biofilm formation transitions from continuum to step-like behavior.

Jan. 24, 2021, 12:30 PM – Jan. 24, 2021, 12:40 PM

Authors

Selena Chiu

Princeton University
Abdul Qadeer Rehan

University of Tennessee, University of York, Old Dominion University, Massachusetts Institute of Technology, Old Dominion University, Massachusetts Institute of Technology, Lawrence Berkeley National Laboratory, University of California, Berkeley, Institute of Physics - University of Sao Paulo, Naval Research Laboratory, St. Cloud State University, University of Illinois at Urbana-Champaign, Space Sciences Laboratory, Virginia Polytechnic Institute and State University, Space Sciences Laboratory, University of California Berkeley, University of Maryland - Baltimore County, Sandia National Laboratories, Pacific Northwest National Laboratory, Federal University of Bahia; University of Brasília, Federal University of Bahia, Department of Applied Physics, Yale University & Department of Physics, Yale University, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Department of Physics, University of Illinois at Urbana-Champaign & Current affiliation: Seagate Research Group, Seagate Technology, Department of Physics and Astronomy, Wayne State University, Department of Physics, University of Illinois at Urbana-Champaign, Department of Applied Physics, Yale University, Swarthmore College, Western Washington University, Departments of Chemistry and Physics and The Baruch 60 Center for Biochemical Solar Energy Research at Rensselaer Polytechnic Institute, University of Florida, Wayne State University, Vanderbilt University, University of Maryland, College Park, NASA GSFC, CfA, California Institute of Technology, Skidmore College, Durham University, University of Alberta, University of Michigan, Curtin University, Michigan State University, University of Nevada, University of Chicago, Duke University, Cornell, Pennsylvania State University, New York University Abu Dhabi, NASA Ames Research Center, Kenyon Coll, Kenyon College, University of Texas at Austin, Flatiron Institute, University of California, Los Angeles, Ohio State University, University of Pennsylvania, HERA, HERA, Rochester Institute of Technology, Howard Community College, Carleton College, California State University at Long Beach, Bishop Ireton High School, Fayetteville State University, Univ of Oklahoma, University of Massachusetts Amherst, Carnegie Observatories, San Diego State University, Associate of the National Institute of Standards and Technology, National Institute of Standards and Technology, NTT Basic Research Laboratories and NTT Research Center for Theoretical Quantum Physics, JILA, University of Colorado, 440 UCB, Boulder, CO, Department of Physics, 390 UCB University of Colorado, University of Washington, James Franck Institute, Enrico Fermi Institute, University of Chicago Department of Physics, Princeton University, Department of Physics, Arizona State University, Indiana Univ - Bloomington, National Autonomous University of Mexico, Harvard University, Nagoya University, Toyota Technological Institute, University of Tokyo, Zhejiang University, Clark University, Natl Univ of Singapore, University of Richmond
Abdul Qadeer Rehan

University of Tennessee, University of York, Old Dominion University, Massachusetts Institute of Technology, Old Dominion University, Massachusetts Institute of Technology, Lawrence Berkeley National Laboratory, University of California, Berkeley, Institute of Physics - University of Sao Paulo, Naval Research Laboratory, St. Cloud State University, University of Illinois at Urbana-Champaign, Space Sciences Laboratory, Virginia Polytechnic Institute and State University, Space Sciences Laboratory, University of California Berkeley, University of Maryland - Baltimore County, Sandia National Laboratories, Pacific Northwest National Laboratory, Federal University of Bahia; University of Brasília, Federal University of Bahia, Department of Applied Physics, Yale University & Department of Physics, Yale University, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Department of Physics, University of Illinois at Urbana-Champaign & Current affiliation: Seagate Research Group, Seagate Technology, Department of Physics and Astronomy, Wayne State University, Department of Physics, University of Illinois at Urbana-Champaign, Department of Applied Physics, Yale University, Swarthmore College, Western Washington University, Departments of Chemistry and Physics and The Baruch 60 Center for Biochemical Solar Energy Research at Rensselaer Polytechnic Institute, University of Florida, Wayne State University, Vanderbilt University, University of Maryland, College Park, NASA GSFC, CfA, California Institute of Technology, Skidmore College, Durham University, University of Alberta, University of Michigan, Curtin University, Michigan State University, University of Nevada, University of Chicago, Duke University, Cornell, Pennsylvania State University, New York University Abu Dhabi, NASA Ames Research Center, Kenyon Coll, Kenyon College, University of Texas at Austin, Flatiron Institute, University of California, Los Angeles, Ohio State University, University of Pennsylvania, HERA, HERA, Rochester Institute of Technology, Howard Community College, Carleton College, California State University at Long Beach, Bishop Ireton High School, Fayetteville State University, Univ of Oklahoma, University of Massachusetts Amherst, Carnegie Observatories, San Diego State University, Associate of the National Institute of Standards and Technology, National Institute of Standards and Technology, NTT Basic Research Laboratories and NTT Research Center for Theoretical Quantum Physics, JILA, University of Colorado, 440 UCB, Boulder, CO, Department of Physics, 390 UCB University of Colorado, University of Washington, James Franck Institute, Enrico Fermi Institute, University of Chicago Department of Physics, Princeton University, Department of Physics, Arizona State University, Indiana Univ - Bloomington, National Autonomous University of Mexico, Harvard University, Nagoya University, Toyota Technological Institute, University of Tokyo, Zhejiang University, Clark University, Natl Univ of Singapore, University of Richmond
Abdul Qadeer Rehan

University of Tennessee, University of York, Old Dominion University, Massachusetts Institute of Technology, Old Dominion University, Massachusetts Institute of Technology, Lawrence Berkeley National Laboratory, University of California, Berkeley, Institute of Physics - University of Sao Paulo, Naval Research Laboratory, St. Cloud State University, University of Illinois at Urbana-Champaign, Space Sciences Laboratory, Virginia Polytechnic Institute and State University, Space Sciences Laboratory, University of California Berkeley, University of Maryland - Baltimore County, Sandia National Laboratories, Pacific Northwest National Laboratory, Federal University of Bahia; University of Brasília, Federal University of Bahia, Department of Applied Physics, Yale University & Department of Physics, Yale University, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Department of Physics, University of Illinois at Urbana-Champaign & Current affiliation: Seagate Research Group, Seagate Technology, Department of Physics and Astronomy, Wayne State University, Department of Physics, University of Illinois at Urbana-Champaign, Department of Applied Physics, Yale University, Swarthmore College, Western Washington University, Departments of Chemistry and Physics and The Baruch 60 Center for Biochemical Solar Energy Research at Rensselaer Polytechnic Institute, University of Florida, Wayne State University, Vanderbilt University, University of Maryland, College Park, NASA GSFC, CfA, California Institute of Technology, Skidmore College, Durham University, University of Alberta, University of Michigan, Curtin University, Michigan State University, University of Nevada, University of Chicago, Duke University, Cornell, Pennsylvania State University, New York University Abu Dhabi, NASA Ames Research Center, Kenyon Coll, Kenyon College, University of Texas at Austin, Flatiron Institute, University of California, Los Angeles, Ohio State University, University of Pennsylvania, HERA, HERA, Rochester Institute of Technology, Howard Community College, Carleton College, California State University at Long Beach, Bishop Ireton High School, Fayetteville State University, Univ of Oklahoma, University of Massachusetts Amherst, Carnegie Observatories, San Diego State University, Associate of the National Institute of Standards and Technology, National Institute of Standards and Technology, NTT Basic Research Laboratories and NTT Research Center for Theoretical Quantum Physics, JILA, University of Colorado, 440 UCB, Boulder, CO, Department of Physics, 390 UCB University of Colorado, University of Washington, James Franck Institute, Enrico Fermi Institute, University of Chicago Department of Physics, Princeton University, Department of Physics, Arizona State University, Indiana Univ - Bloomington, National Autonomous University of Mexico, Harvard University, Nagoya University, Toyota Technological Institute, University of Tokyo, Zhejiang University, Clark University, Natl Univ of Singapore, University of Richmond
Abdul Qadeer Rehan

University of Tennessee, University of York, Old Dominion University, Massachusetts Institute of Technology, Old Dominion University, Massachusetts Institute of Technology, Lawrence Berkeley National Laboratory, University of California, Berkeley, Institute of Physics - University of Sao Paulo, Naval Research Laboratory, St. Cloud State University, University of Illinois at Urbana-Champaign, Space Sciences Laboratory, Virginia Polytechnic Institute and State University, Space Sciences Laboratory, University of California Berkeley, University of Maryland - Baltimore County, Sandia National Laboratories, Pacific Northwest National Laboratory, Federal University of Bahia; University of Brasília, Federal University of Bahia, Department of Applied Physics, Yale University & Department of Physics, Yale University, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Department of Physics, University of Illinois at Urbana-Champaign & Current affiliation: Seagate Research Group, Seagate Technology, Department of Physics and Astronomy, Wayne State University, Department of Physics, University of Illinois at Urbana-Champaign, Department of Applied Physics, Yale University, Swarthmore College, Western Washington University, Departments of Chemistry and Physics and The Baruch 60 Center for Biochemical Solar Energy Research at Rensselaer Polytechnic Institute, University of Florida, Wayne State University, Vanderbilt University, University of Maryland, College Park, NASA GSFC, CfA, California Institute of Technology, Skidmore College, Durham University, University of Alberta, University of Michigan, Curtin University, Michigan State University, University of Nevada, University of Chicago, Duke University, Cornell, Pennsylvania State University, New York University Abu Dhabi, NASA Ames Research Center, Kenyon Coll, Kenyon College, University of Texas at Austin, Flatiron Institute, University of California, Los Angeles, Ohio State University, University of Pennsylvania, HERA, HERA, Rochester Institute of Technology, Howard Community College, Carleton College, California State University at Long Beach, Bishop Ireton High School, Fayetteville State University, Univ of Oklahoma, University of Massachusetts Amherst, Carnegie Observatories, San Diego State University, Associate of the National Institute of Standards and Technology, National Institute of Standards and Technology, NTT Basic Research Laboratories and NTT Research Center for Theoretical Quantum Physics, JILA, University of Colorado, 440 UCB, Boulder, CO, Department of Physics, 390 UCB University of Colorado, University of Washington, James Franck Institute, Enrico Fermi Institute, University of Chicago Department of Physics, Princeton University, Department of Physics, Arizona State University, Indiana Univ - Bloomington, National Autonomous University of Mexico, Harvard University, Nagoya University, Toyota Technological Institute, University of Tokyo, Zhejiang University, Clark University, Natl Univ of Singapore, University of Richmond