Geant4 Microdosimetry for Simulation of Dose Enhancement in vivo at Orthovoltage Energy

ORAL

Abstract

Dose-enhanced radiotherapy utilizes high-Z materials at a tumor site to increase the local dose from external beam radiotherapy. This effect is due to the increased cross section from the photoelectric effect and the production of Auger electrons. Many past simulations calculated dose in millimeter-scale voxels and ignored heterogeneities in concentration as well as sites of dose deposition at the cellular scale. We develop a cellular-scale Monte Carlo model using Geant4 to predict the dose enhancement in a variety of scenarios. Gold, tungsten, and iodine are simulated in both in vitro and in vivo geometries. We vary the concentration of the contrast agent both internal and external to the cell, and we measure dose only in the nuclear volume, where DNA damage occurs.

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Authors

  • Nicole Ackerman

    Physics Dept, Stanford University

  • G.V. Brown

    Department of Physics at CSU, Fresno, Lawrence Livermore National Laboratory, Stanford University, Advanced Light Source, Lawrence Berkeley National Lab, Nanoelectronics Research Institute, Japan Atomic Energy Agency, University of Tokyo, Cornell University, Tokyo Institute of Technology, Suranaree University of Technology, Shandong University, Stanford Synchrotron Radiation Lightsource, UC Davis, CSU Dominguez Hills, Thomas Jefferson National Accelerator Facility, UC Berkeley, ANL, UChicago/ANL, UManitoba, Northwestern U/ANL, LLNL, UCB/LLNL, McGill U, McGill U/ANL, University of Nevada, Reno, Hitachi Global Storage Technology, Advanced Light Source, Stanford Synchrotron Radiation Laboratory, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Materials Science and Engineering, Stanford University, Radiation Oncology, Stanford University School of Medicine, Missouri University of Science and Technology, International Institute of Physics, University of Missouri, University of Notre Dame du Lac, Department of Physics, California State University, Fresno, California, California State University Long Beach, BNL, IWF Dresden, Department of Physics, University of California, Davis, CA 95616, USA, University of California, Merced, Laboratoire Univers et Particules de Montpellier, IN2P3 (France), SLAC National Accelerator Laboratory/Stanford University/KIPAC, University of Perugia, University of Washington, CEA/Saclay, UNR, UNM, UCSD, RAL, ILE, MIT, LANL, LLE, NRL, SLAC National Accelerator Laboratory, Technische Universitaet Berlin, Max Born Institut, Hiroshima University, Western Michigan University, MPIK

  • G.V. Brown

    Department of Physics at CSU, Fresno, Lawrence Livermore National Laboratory, Stanford University, Advanced Light Source, Lawrence Berkeley National Lab, Nanoelectronics Research Institute, Japan Atomic Energy Agency, University of Tokyo, Cornell University, Tokyo Institute of Technology, Suranaree University of Technology, Shandong University, Stanford Synchrotron Radiation Lightsource, UC Davis, CSU Dominguez Hills, Thomas Jefferson National Accelerator Facility, UC Berkeley, ANL, UChicago/ANL, UManitoba, Northwestern U/ANL, LLNL, UCB/LLNL, McGill U, McGill U/ANL, University of Nevada, Reno, Hitachi Global Storage Technology, Advanced Light Source, Stanford Synchrotron Radiation Laboratory, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Materials Science and Engineering, Stanford University, Radiation Oncology, Stanford University School of Medicine, Missouri University of Science and Technology, International Institute of Physics, University of Missouri, University of Notre Dame du Lac, Department of Physics, California State University, Fresno, California, California State University Long Beach, BNL, IWF Dresden, Department of Physics, University of California, Davis, CA 95616, USA, University of California, Merced, Laboratoire Univers et Particules de Montpellier, IN2P3 (France), SLAC National Accelerator Laboratory/Stanford University/KIPAC, University of Perugia, University of Washington, CEA/Saclay, UNR, UNM, UCSD, RAL, ILE, MIT, LANL, LLE, NRL, SLAC National Accelerator Laboratory, Technische Universitaet Berlin, Max Born Institut, Hiroshima University, Western Michigan University, MPIK