Computational Approach for Quantifying Structural Disorder in Biomolecular Lattices

ORAL

Abstract

We have developed a novel computational approach for quantifying structural disorder in biomolecular lattices with nonlinear susceptibility based on analysis of polarization-modulated second harmonic signal. Transient, regional disorder at the level of molecular organization is identified using a novel signal-processing algorithms sufficiently compact for near real-time analysis with a desktop computer. Global disorder and regional disorder within the biostructure are assessed and scored using a multiple methodologies. Experimental results suggest our signal processing method represents a robust, scalable tool that allows us to detect both regional and global alterations in signal characteristics of biostructures with a high degree of discrimination.

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Authors

  • Clayton Bratton

    University of California, Davis - Physics

  • Joshua Lusk

    University of New Mexico, Gallup Campus, Sciprint.org, Institute of Gravitation and Cosmology, Moscow, Russia, CSU Long Beach, California State University - East Bay, LLNL, UC Santa Cruz, University of California, Berkeley, Loma Linda Medical University, Northern Illinois University, Santa Cruz Institute for Particle Physics, Dr, Pr, California State University Long Beach, California Polytechnic State University, Department of Physics, California State University, Fresno, NPS, UC-Davis, University of California-Davis, University of California Riverside, Rutgers University, Pomona College, Department of Physics, Imperial College London, Materials Research Laboratory, UC Santa Barbara, Naval Postgraduate School, Whittier College, Cardiff University, Cardiff, Wales - Cardiff School of Biosciences, University of California, Davis - Electrical and Computer Engineering, University of California, Davis - Neurosurgery, Materials Department, University of California, Santa Barbara, CA 93106-5050, Queen's University, Belfast, Rutherford Appleton Laboratory, Technical University of Darmstadt, University of York, University of California, Los Angeles, Kohat University of Science and Technology, Lawrence Livermore National Laboratory, Imperial College, The Blackett Laboratory, University of Strathclyde, University of Oxford, UC Berkeley, UC Berkeley, SLAC, Gesellschaft f\"ur Schwerionenforschung GSI, University of Washington, Seattle, LLNL and XIA LLC, University of Graz, University of California, Davis, Naval Surface Warfare Center-Indian Head Division

  • Joshua Lusk

    University of New Mexico, Gallup Campus, Sciprint.org, Institute of Gravitation and Cosmology, Moscow, Russia, CSU Long Beach, California State University - East Bay, LLNL, UC Santa Cruz, University of California, Berkeley, Loma Linda Medical University, Northern Illinois University, Santa Cruz Institute for Particle Physics, Dr, Pr, California State University Long Beach, California Polytechnic State University, Department of Physics, California State University, Fresno, NPS, UC-Davis, University of California-Davis, University of California Riverside, Rutgers University, Pomona College, Department of Physics, Imperial College London, Materials Research Laboratory, UC Santa Barbara, Naval Postgraduate School, Whittier College, Cardiff University, Cardiff, Wales - Cardiff School of Biosciences, University of California, Davis - Electrical and Computer Engineering, University of California, Davis - Neurosurgery, Materials Department, University of California, Santa Barbara, CA 93106-5050, Queen's University, Belfast, Rutherford Appleton Laboratory, Technical University of Darmstadt, University of York, University of California, Los Angeles, Kohat University of Science and Technology, Lawrence Livermore National Laboratory, Imperial College, The Blackett Laboratory, University of Strathclyde, University of Oxford, UC Berkeley, UC Berkeley, SLAC, Gesellschaft f\"ur Schwerionenforschung GSI, University of Washington, Seattle, LLNL and XIA LLC, University of Graz, University of California, Davis, Naval Surface Warfare Center-Indian Head Division

  • Joshua Lusk

    University of New Mexico, Gallup Campus, Sciprint.org, Institute of Gravitation and Cosmology, Moscow, Russia, CSU Long Beach, California State University - East Bay, LLNL, UC Santa Cruz, University of California, Berkeley, Loma Linda Medical University, Northern Illinois University, Santa Cruz Institute for Particle Physics, Dr, Pr, California State University Long Beach, California Polytechnic State University, Department of Physics, California State University, Fresno, NPS, UC-Davis, University of California-Davis, University of California Riverside, Rutgers University, Pomona College, Department of Physics, Imperial College London, Materials Research Laboratory, UC Santa Barbara, Naval Postgraduate School, Whittier College, Cardiff University, Cardiff, Wales - Cardiff School of Biosciences, University of California, Davis - Electrical and Computer Engineering, University of California, Davis - Neurosurgery, Materials Department, University of California, Santa Barbara, CA 93106-5050, Queen's University, Belfast, Rutherford Appleton Laboratory, Technical University of Darmstadt, University of York, University of California, Los Angeles, Kohat University of Science and Technology, Lawrence Livermore National Laboratory, Imperial College, The Blackett Laboratory, University of Strathclyde, University of Oxford, UC Berkeley, UC Berkeley, SLAC, Gesellschaft f\"ur Schwerionenforschung GSI, University of Washington, Seattle, LLNL and XIA LLC, University of Graz, University of California, Davis, Naval Surface Warfare Center-Indian Head Division

  • Joshua Lusk

    University of New Mexico, Gallup Campus, Sciprint.org, Institute of Gravitation and Cosmology, Moscow, Russia, CSU Long Beach, California State University - East Bay, LLNL, UC Santa Cruz, University of California, Berkeley, Loma Linda Medical University, Northern Illinois University, Santa Cruz Institute for Particle Physics, Dr, Pr, California State University Long Beach, California Polytechnic State University, Department of Physics, California State University, Fresno, NPS, UC-Davis, University of California-Davis, University of California Riverside, Rutgers University, Pomona College, Department of Physics, Imperial College London, Materials Research Laboratory, UC Santa Barbara, Naval Postgraduate School, Whittier College, Cardiff University, Cardiff, Wales - Cardiff School of Biosciences, University of California, Davis - Electrical and Computer Engineering, University of California, Davis - Neurosurgery, Materials Department, University of California, Santa Barbara, CA 93106-5050, Queen's University, Belfast, Rutherford Appleton Laboratory, Technical University of Darmstadt, University of York, University of California, Los Angeles, Kohat University of Science and Technology, Lawrence Livermore National Laboratory, Imperial College, The Blackett Laboratory, University of Strathclyde, University of Oxford, UC Berkeley, UC Berkeley, SLAC, Gesellschaft f\"ur Schwerionenforschung GSI, University of Washington, Seattle, LLNL and XIA LLC, University of Graz, University of California, Davis, Naval Surface Warfare Center-Indian Head Division

  • Joshua Lusk

    University of New Mexico, Gallup Campus, Sciprint.org, Institute of Gravitation and Cosmology, Moscow, Russia, CSU Long Beach, California State University - East Bay, LLNL, UC Santa Cruz, University of California, Berkeley, Loma Linda Medical University, Northern Illinois University, Santa Cruz Institute for Particle Physics, Dr, Pr, California State University Long Beach, California Polytechnic State University, Department of Physics, California State University, Fresno, NPS, UC-Davis, University of California-Davis, University of California Riverside, Rutgers University, Pomona College, Department of Physics, Imperial College London, Materials Research Laboratory, UC Santa Barbara, Naval Postgraduate School, Whittier College, Cardiff University, Cardiff, Wales - Cardiff School of Biosciences, University of California, Davis - Electrical and Computer Engineering, University of California, Davis - Neurosurgery, Materials Department, University of California, Santa Barbara, CA 93106-5050, Queen's University, Belfast, Rutherford Appleton Laboratory, Technical University of Darmstadt, University of York, University of California, Los Angeles, Kohat University of Science and Technology, Lawrence Livermore National Laboratory, Imperial College, The Blackett Laboratory, University of Strathclyde, University of Oxford, UC Berkeley, UC Berkeley, SLAC, Gesellschaft f\"ur Schwerionenforschung GSI, University of Washington, Seattle, LLNL and XIA LLC, University of Graz, University of California, Davis, Naval Surface Warfare Center-Indian Head Division