Neutrino Target-of-Opportunity Observations with EUSO-SPB2

Cosmic-ray accelerators capable of reaching ultra-high energies are expected to also produce very-high energy neutrinos via hadronic interactions within the source or its surrounding environment. Many of the candidate astrophysical source classes are either explicitly transient or exhibit flaring activity. Leveraging the Earth as a neutrino converter, suborbital and space-based optical Cherenkov detectors will be able to detect upward-moving extensive air showers induced by decay tau-leptons generated from cosmic tau neutrinos with energies ~ 10 PeV and above, reaching sensitivities at the level of modeled neutrino fluences for nearby astrophysical transients. We discuss the prospects of detecting tau neutrino events from astrophysical transients with the NASA super-pressure balloon mission EUSO-SPB2 as well as our preparations for neutrino Target-of-Opportunity observations during its upcoming flight in Spring 2023.