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Nuclear imaging of iodine uptake in mouse tissues

ORAL

Abstract

We have designed and employed a compact gamma camera based on pixellated scintillators and position-sensitive photomultipliers to obtain in vivo images in mice of biological substances tagged with 125-I. Biomedical imaging studies make use of radioactive isotopes of iodine. In these applications, protection of the thyroid from the effects of the radioactive material can be important. We have studied \textit{in vivo} the effectiveness in mice of pre-administration of KI in various concentrations to evaluate both the biologically effective doses for thyroid protection and the potential for use in general sodium iodide symporter studies. These findings have important implications for both intentional and accidental exposure to radioiodine.

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Authors

  • W.T. Hammond

  • Raffaella De Vita

    Kent State University, Jefferson Lab, Ohio University, Mainz University, Mainz, Germany, Max-Planck-Institute for Nuclear Physics, Heidelberg, Germany, University of Washington, Noncommercial Partnership ``Scientific Instruments,'' Moscow, Russia, Lucent Technologies, North-West Technical University, St. Petersburg, Russia, Indiana University-Purdue University Indianapolis, Purdue University, University of Florida, Wabash College and Purdue University, University of Oregon, Garnett McKeen Lab, Inc., Korea Research Institute of Standards and Science, Daejeon, South Korea, 305-600, Department of Physics, Lab. of Solid State Microstructure, Nanjing University, Nanjing, 200008, China, Department of Physics, Hampton University, Hampton, VA 23668, NESB, NASA Langley Research Center, Hampton, VA 23681, Korea Research Institute of Stardards and Science, Daejeon, South Korea, 305-600, Department of Chemical Engineering, Sogang University, South Korea, 121-742, Indiana University, University of Chicago, LBNL, BNL/NSLS, KEK, Fermi National Accelerator Laboratory, LANL, University of Maryland, NIST, HMI, Harvard University, NCSU, Department of Physics and Astronomy, University of Nebraska, University of Southern California, University of California at Los Angeles, Stanford Linear Accelerator Center, Institute for Advanced Physics, Konkuk University, Korea, SUNY College at Oneonta, Department of Physics, University of Wisconsin-Whitewater, Whitewater WI 53190, Cyclotron Institute, Texas A\&M University, College Station, TX, University of Texas at El Paso, University of Buenos Aires, Cyclotron Institute, Texas A\&M University, College Station, TX 77843, Simon Bolivar University, Caracas, Venezuela, Warsaw University, Warsaw, Poland, Institut de Recherches Subatomiques, Strasbourg, France, Florida State University, Harvard-Smithsonian CfA, CENPA University of Washington, Pasadena City College, California State University, Northridge, California State University, Dominguez Hills, Chinese University of Hong Kong, Jet Propulsion Lab, California Institute of Technology, University of California, Irvine, Instituto de F\'isica, UNAM, University of Toronto, Friedrich-Schiller-Universitaet Jena, Pennsylvania State University, NIH, Stanford University, CNR, Italy, University of Texas, Austin, University of Nevada, Reno, University of Wisconsin-Madison, Hanseo University, Division of Materials Science and Technology, KIST, Seoul, 130-791, Korea, Department of Physics, Kangwon National University, Chuncheon, 200-701, Korea, Department of Techno-marketing, Mokwon University, Taejeon, 301-729, Korea, Institute of Physics and Applied Physics, Yonsei University, Seoul, 120-749, Korea, UNAM, Mexico, JINR, Dubna, Univ. of Notre-Dame, ANL, SUNY at Stony Brook, Lund U., ORNL, Washington U., Warsaw, Poland, Saclay, France, Boston University, National Institute for Standards and Technology, Boulder, Los Alamos National Laboratory, Yale University, Florida International University, MIT, Saint Mary's University, TRI-University Meson Facility, Institute of Nuclear Physics, Prague, Czech Republic, Institute of Physics and Nuclear Engineering, Bucharest, Romania, Cyclotron Institute, Texas A\&M Univ., Physics Division, Argonne National Laboratory, Wright Nuclear Structure Laboratory, Yale University, Tenn. Tech. Univ., Arizona State Univ., Ohio Univ., Tennessee Technologival Univ., ORNL Physics Division, Laboratory for High Energy Astrophysics, NASA Goddard Space Flight Center, University of California, CEA, LLNL, Penn State Altoona, NC A&T State University, TUNL, NASA Langley Research Center, University of Iowa, UMD \& NASA/GSFC, NRC \& NASA/GSFC, NASA/GSFC, Academy at UAH, Oak Ridge National Laboratory, North Carolina State University, Union College, University of Hamburg, Iowa State University, Drake University, Lawrence Livermore National Laboratory, University of Arizona, UNC, Chapel Hill, NC, Tennessee Tech., Cookeville, TN, Rutgers Univ., New Brunswick, NJ, ORNL, Oak Ridge, TN, ORAU, Oak Ridge, TN, Collegium of Natural Sciences, Eckerd College, RIKEN (Institute of Physical and Chemical Research), Department of Physics, Rikkyo University, Department of Physics, University of Tokyo, Department of Physics and Astronomy and National Superconducting Cyclotron Laboratory, Michigan State University, Tokyo Inst. of Tech., Rikkyo Univ., Univ. of Tokyo, RIKEN, NSCL, Michigan State University, Dept. of Physics, University of Surrey, Guildford, UK, National Superconducting Cyclotron Laboratory, Michigan State University, University of Surrey, UK, IRES CNRS Strasbourg, Planetary Science Institute, Steward Observatory, University of Oklahoma, Vatican Observatory, University of Rochester, UIUC, Washington State University, Johns Hopkins University, Istituto Nazionale di Fisica Nucleare-Genova

  • Raffaella De Vita

    Kent State University, Jefferson Lab, Ohio University, Mainz University, Mainz, Germany, Max-Planck-Institute for Nuclear Physics, Heidelberg, Germany, University of Washington, Noncommercial Partnership ``Scientific Instruments,'' Moscow, Russia, Lucent Technologies, North-West Technical University, St. Petersburg, Russia, Indiana University-Purdue University Indianapolis, Purdue University, University of Florida, Wabash College and Purdue University, University of Oregon, Garnett McKeen Lab, Inc., Korea Research Institute of Standards and Science, Daejeon, South Korea, 305-600, Department of Physics, Lab. of Solid State Microstructure, Nanjing University, Nanjing, 200008, China, Department of Physics, Hampton University, Hampton, VA 23668, NESB, NASA Langley Research Center, Hampton, VA 23681, Korea Research Institute of Stardards and Science, Daejeon, South Korea, 305-600, Department of Chemical Engineering, Sogang University, South Korea, 121-742, Indiana University, University of Chicago, LBNL, BNL/NSLS, KEK, Fermi National Accelerator Laboratory, LANL, University of Maryland, NIST, HMI, Harvard University, NCSU, Department of Physics and Astronomy, University of Nebraska, University of Southern California, University of California at Los Angeles, Stanford Linear Accelerator Center, Institute for Advanced Physics, Konkuk University, Korea, SUNY College at Oneonta, Department of Physics, University of Wisconsin-Whitewater, Whitewater WI 53190, Cyclotron Institute, Texas A\&M University, College Station, TX, University of Texas at El Paso, University of Buenos Aires, Cyclotron Institute, Texas A\&M University, College Station, TX 77843, Simon Bolivar University, Caracas, Venezuela, Warsaw University, Warsaw, Poland, Institut de Recherches Subatomiques, Strasbourg, France, Florida State University, Harvard-Smithsonian CfA, CENPA University of Washington, Pasadena City College, California State University, Northridge, California State University, Dominguez Hills, Chinese University of Hong Kong, Jet Propulsion Lab, California Institute of Technology, University of California, Irvine, Instituto de F\'isica, UNAM, University of Toronto, Friedrich-Schiller-Universitaet Jena, Pennsylvania State University, NIH, Stanford University, CNR, Italy, University of Texas, Austin, University of Nevada, Reno, University of Wisconsin-Madison, Hanseo University, Division of Materials Science and Technology, KIST, Seoul, 130-791, Korea, Department of Physics, Kangwon National University, Chuncheon, 200-701, Korea, Department of Techno-marketing, Mokwon University, Taejeon, 301-729, Korea, Institute of Physics and Applied Physics, Yonsei University, Seoul, 120-749, Korea, UNAM, Mexico, JINR, Dubna, Univ. of Notre-Dame, ANL, SUNY at Stony Brook, Lund U., ORNL, Washington U., Warsaw, Poland, Saclay, France, Boston University, National Institute for Standards and Technology, Boulder, Los Alamos National Laboratory, Yale University, Florida International University, MIT, Saint Mary's University, TRI-University Meson Facility, Institute of Nuclear Physics, Prague, Czech Republic, Institute of Physics and Nuclear Engineering, Bucharest, Romania, Cyclotron Institute, Texas A\&M Univ., Physics Division, Argonne National Laboratory, Wright Nuclear Structure Laboratory, Yale University, Tenn. Tech. Univ., Arizona State Univ., Ohio Univ., Tennessee Technologival Univ., ORNL Physics Division, Laboratory for High Energy Astrophysics, NASA Goddard Space Flight Center, University of California, CEA, LLNL, Penn State Altoona, NC A&T State University, TUNL, NASA Langley Research Center, University of Iowa, UMD \& NASA/GSFC, NRC \& NASA/GSFC, NASA/GSFC, Academy at UAH, Oak Ridge National Laboratory, North Carolina State University, Union College, University of Hamburg, Iowa State University, Drake University, Lawrence Livermore National Laboratory, University of Arizona, UNC, Chapel Hill, NC, Tennessee Tech., Cookeville, TN, Rutgers Univ., New Brunswick, NJ, ORNL, Oak Ridge, TN, ORAU, Oak Ridge, TN, Collegium of Natural Sciences, Eckerd College, RIKEN (Institute of Physical and Chemical Research), Department of Physics, Rikkyo University, Department of Physics, University of Tokyo, Department of Physics and Astronomy and National Superconducting Cyclotron Laboratory, Michigan State University, Tokyo Inst. of Tech., Rikkyo Univ., Univ. of Tokyo, RIKEN, NSCL, Michigan State University, Dept. of Physics, University of Surrey, Guildford, UK, National Superconducting Cyclotron Laboratory, Michigan State University, University of Surrey, UK, IRES CNRS Strasbourg, Planetary Science Institute, Steward Observatory, University of Oklahoma, Vatican Observatory, University of Rochester, UIUC, Washington State University, Johns Hopkins University, Istituto Nazionale di Fisica Nucleare-Genova

  • Raffaella De Vita

    Kent State University, Jefferson Lab, Ohio University, Mainz University, Mainz, Germany, Max-Planck-Institute for Nuclear Physics, Heidelberg, Germany, University of Washington, Noncommercial Partnership ``Scientific Instruments,'' Moscow, Russia, Lucent Technologies, North-West Technical University, St. Petersburg, Russia, Indiana University-Purdue University Indianapolis, Purdue University, University of Florida, Wabash College and Purdue University, University of Oregon, Garnett McKeen Lab, Inc., Korea Research Institute of Standards and Science, Daejeon, South Korea, 305-600, Department of Physics, Lab. of Solid State Microstructure, Nanjing University, Nanjing, 200008, China, Department of Physics, Hampton University, Hampton, VA 23668, NESB, NASA Langley Research Center, Hampton, VA 23681, Korea Research Institute of Stardards and Science, Daejeon, South Korea, 305-600, Department of Chemical Engineering, Sogang University, South Korea, 121-742, Indiana University, University of Chicago, LBNL, BNL/NSLS, KEK, Fermi National Accelerator Laboratory, LANL, University of Maryland, NIST, HMI, Harvard University, NCSU, Department of Physics and Astronomy, University of Nebraska, University of Southern California, University of California at Los Angeles, Stanford Linear Accelerator Center, Institute for Advanced Physics, Konkuk University, Korea, SUNY College at Oneonta, Department of Physics, University of Wisconsin-Whitewater, Whitewater WI 53190, Cyclotron Institute, Texas A\&M University, College Station, TX, University of Texas at El Paso, University of Buenos Aires, Cyclotron Institute, Texas A\&M University, College Station, TX 77843, Simon Bolivar University, Caracas, Venezuela, Warsaw University, Warsaw, Poland, Institut de Recherches Subatomiques, Strasbourg, France, Florida State University, Harvard-Smithsonian CfA, CENPA University of Washington, Pasadena City College, California State University, Northridge, California State University, Dominguez Hills, Chinese University of Hong Kong, Jet Propulsion Lab, California Institute of Technology, University of California, Irvine, Instituto de F\'isica, UNAM, University of Toronto, Friedrich-Schiller-Universitaet Jena, Pennsylvania State University, NIH, Stanford University, CNR, Italy, University of Texas, Austin, University of Nevada, Reno, University of Wisconsin-Madison, Hanseo University, Division of Materials Science and Technology, KIST, Seoul, 130-791, Korea, Department of Physics, Kangwon National University, Chuncheon, 200-701, Korea, Department of Techno-marketing, Mokwon University, Taejeon, 301-729, Korea, Institute of Physics and Applied Physics, Yonsei University, Seoul, 120-749, Korea, UNAM, Mexico, JINR, Dubna, Univ. of Notre-Dame, ANL, SUNY at Stony Brook, Lund U., ORNL, Washington U., Warsaw, Poland, Saclay, France, Boston University, National Institute for Standards and Technology, Boulder, Los Alamos National Laboratory, Yale University, Florida International University, MIT, Saint Mary's University, TRI-University Meson Facility, Institute of Nuclear Physics, Prague, Czech Republic, Institute of Physics and Nuclear Engineering, Bucharest, Romania, Cyclotron Institute, Texas A\&M Univ., Physics Division, Argonne National Laboratory, Wright Nuclear Structure Laboratory, Yale University, Tenn. Tech. Univ., Arizona State Univ., Ohio Univ., Tennessee Technologival Univ., ORNL Physics Division, Laboratory for High Energy Astrophysics, NASA Goddard Space Flight Center, University of California, CEA, LLNL, Penn State Altoona, NC A&T State University, TUNL, NASA Langley Research Center, University of Iowa, UMD \& NASA/GSFC, NRC \& NASA/GSFC, NASA/GSFC, Academy at UAH, Oak Ridge National Laboratory, North Carolina State University, Union College, University of Hamburg, Iowa State University, Drake University, Lawrence Livermore National Laboratory, University of Arizona, UNC, Chapel Hill, NC, Tennessee Tech., Cookeville, TN, Rutgers Univ., New Brunswick, NJ, ORNL, Oak Ridge, TN, ORAU, Oak Ridge, TN, Collegium of Natural Sciences, Eckerd College, RIKEN (Institute of Physical and Chemical Research), Department of Physics, Rikkyo University, Department of Physics, University of Tokyo, Department of Physics and Astronomy and National Superconducting Cyclotron Laboratory, Michigan State University, Tokyo Inst. of Tech., Rikkyo Univ., Univ. of Tokyo, RIKEN, NSCL, Michigan State University, Dept. of Physics, University of Surrey, Guildford, UK, National Superconducting Cyclotron Laboratory, Michigan State University, University of Surrey, UK, IRES CNRS Strasbourg, Planetary Science Institute, Steward Observatory, University of Oklahoma, Vatican Observatory, University of Rochester, UIUC, Washington State University, Johns Hopkins University, Istituto Nazionale di Fisica Nucleare-Genova

  • R.E. Welsh

    Physics, William and Mary

  • E.L. Bradley

  • M.S. Saha

    Biology, William and Mary

  • J. Qian

    Appl. Sci, William and Mary

  • S. Majewski

  • V. Popov

  • M.F. Smith

  • A.G. Weisenberger

    Jefferson Lab/TJNAF