Characterization of novel 3d printed models in delayed aneurysm rupture after flow diversion treatment.

Intra-aneurysmal thrombi can lead to the weakening of arterial walls at the sites treated with flow diversion, and can result in delayed arterial ruptures (DAR). It is hypothesized that matrix metalloproteinases (MMP), which are released as an inflammatory response, weaken the extracellular matrix resulting in DAR. 3D printed models of arterial aneurysms may provide a useful testing platform to improve aneurysm treatment methods. Understanding the mechanical properties of arterial tissue exposed to MMPs will allow the generation of more accurate models for this purpose, but arterial tissue is a complex, composite material, exhibiting elastic, plastic, and viscoelastic properties. In this work, atomic force microscopy (AFM) is used to measure mechanical properties of the 3D printed materials with the goal of doing similar measurements on arterial tissue exposed to MMPs. Results and challenges of this non-destructive approach to characterization of these systems will be presented.