New Algorithm for Small Volume, Fast, Accurate Blood Analysis (FABA) for Blood Diagnostics via Hand-Held XRF on Drops Rapidly Solidified into Uniform Thin Films

ORAL

Abstract

Comprehensive Blood Diagnostics (BD) uses mLs of blood, and hours to days for results. BD leads to a 74{\%} rate of a serious illness, Hospital-Acquired-Anemia, in chronically ill patients. In this work, a new, fast, portable, comprehensive Small Volume BD device, InnovaStrip [1], solidifies drops into Homogeneous Thin Solid Films (HTSF). Using micro-Ls, HTSFs yield electrolytes and metals levels to $+$/- 10{\%}, the medical standard, using Ion Beam Analysis and X-ray Fluorescence (XRF). Therefore, a new, Fast , Accurate Blood Analysis (FABA) [1] algorithm has to interface InnovaStrip with PCs/smartphones. FABA is developed initially for a low cost, hand-held XRF of HTSF App, called Fast Hand-Held Analysis for XRF(FHAX). Present XRF analysis software such as Spectra.Elements do not measure trace elements to $+$/- 10{\%} because curve fitting focuses large XRF signals for all elements, not small trace element signals [1]. FABA extracts actual Riemann sum of X-ray counts for each selected trace element. FABA yields fast (\textless 5 min), accurate BD to $+$/-10{\%} of blood electrolytes and metals, in mg/dL not atomic {\%} , via built-in HTSF of calibration solutions in InnovaStrip. [1] Balasooriya, Herbots, \textit{et al.} Pat. Pend. (2020)

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Authors

  • Thillina Balasooriya

    MicroDrop Diagnostics LLC, Arizona State University, Dept. of Physics, Arizona State University

  • Wesley Peng

    MicroDrop Diagnostics LLC, Arizona State University, Dept. of Physics, Arizona State University

  • Nikhil Suresh

    MicroDrop Diagnostics LLC, Arizona State University, Dept. of Physics, Arizona State University

  • Aashi Gurijala

    MicroDrop Diagnostics LLC, Arizona State University, Dept. of Physics, Arizona State University

  • Mohammed Sahal

    MicroDrop Diagnostics LLC, Arizona State University, Dept. of Physics, Arizona State University Department of Physics, Arizona State University

  • Nicole Herbots

    Alzheimer Bio-Sensors, LLC, MicroDrop Diagnostics LLC, Arizona State University, Dept. of Physics, SiO2 Innovates LLC., Microdrop Diagnostics, LLC

  • Robert Culbertson

    Arizona State University, Dept. of Physics, Arizona State University Department of Physics, Arizona State University

  • Barry Ritchie

    University of New Mexico, Ion Linac Systems, Tech-X Corporation, Los Alamos National Laboratory, Ronald Reagan UCLA Medical Center, Brigham Young University, Brigham Young University - Provo, United States Air Force Academy, university of Michigan, SISSA, Trieste, Stanford University, Worcester Polytechnic Institute, Grinnell College, Department of Physics, Arizona State University, Brookhaven National Laboratory, University of Southern California, Argonne National Laboratory, Department of Electrical and Computer Engineering, University of New Mexico, Department of Electrical and Computer Engineering and Department of Mechanical Engineering, University of New Mexico, Lock Haven University, Illinois State University, Department of Physics, Utah State University, Logan, Utah, 84322, Department of Physics, New Mexico State University, Las Cruces, New Mexico 88003, USA, Department of Materials, Devices, and Energy Technologies, Sandia National Laboratories, Albuquerque, New Mexico 87185, USA, Kyoto University, University of Guadalajara, University of Florida, Embry-Riddle Aeronautical University, Air Force Research Laboratory, Space Vehicles Directorate, Assurance Technology Corporation, Carlisle, MA, Georgia Tech Research Institute, Atlanta, GA, Utah State University, Georgia Institute of Technology, University of Tennessee, Knoxville, Arizona State University, Department of Physics, United States Air Force Academy, 80840 USAFA, CO, USA, Shaffer Consulting Inc, Max Planck Institute for Astrophysics, Harvard University, Max Planck Institute for Gravitational Physics, Albert Einstein Institute, ASU