Rapid Solidification of Micro-L Blood Drops Into Homogeneous Thin Solid Films: A New Device, InnovaStrip, for Fast, Accurate, Comprehensive Small Volume Blood Diagnostics via Ion Beam Analysis and X-Ray Fluorescence

Blood Diagnostics (BD) analyzes 1-10 mL of liquid blood in hrs to days. BD leads to greater than 80{\%} rates of Hospital-Acquired Anemia - a serious illness for cancer patients and premature infants. In this work, a new, Small Volume BD device, InnovaStrip$^{\mathrm{1}}$, rapidly solidifies blood drops into flat, Homogeneous Thin Solid Films (HTSF). Hyper-hydrophilic HemaDrop$^{\mathrm{1}}$ coatings on InnovaStrip$^{\mathrm{1}}$ are optimized via micro-fluidics to yield HTSFs fit for solid state analysis.~HTSFs undergo Ion Beam Analysis and X-ray Photoelectron Spectroscopy in vacuo and X-ray Fluorescence (XRF) in air without significant radiation damage. They yield electrolytes and metals levels in min. with accuracy and reproducibility to $+$/-10{\%}. Hand-held XRF can be used at Point-of-Care.~Built-in HTSFs from calibration solutions on InnovaStrip$^{\mathrm{1}}$ benchmark HTSF and conversion of atomic {\%} into mg/dL, a key unit for BD.~InnovaStrip$^{\mathrm{1}}$ yields comprehensive BD using micro-Ls instead of mLs of blood. [1] Herbots, Suresh, Peng \textit{et al}. Int. US. Pat. Pend (2020).