Using THz Spectroscopy to Identify Fibrotic Tissue due to Idiopathic Pulmonary Fibrosis

ORAL

Abstract

Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disease that causes irreversible progressive scarring of interstitial lung tissue, and is almost always terminal within 3-5 years. Though there are known risk factors, the exact cause of the disease remains unknown. Current IPF diagnosis is challenging because it is based on visual tests (such as optical tissue images and high-resolution micro CT scans) that can be influenced by interobserver variation. Currently there is no objective, quantifiable method of diagnosing IPF. Due to the success in using THz spectroscopy to identify and image specific biomarkers in other systems, we are developing THz bioimaging histological methods that can provide an objective way to identify fibrotic tissue and diagnose idiopathic pulmonary fibrosis. I will discuss preliminary results showing we can distinguish different components in tissue samples. Current imaging times are long (several hours), and so I will also discuss our progress in constructing a high-speed THz imaging system.

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Authors

  • Alessandra Hoopes

    Brigham Young University - Provo

  • John Spence

    Brigham Young University, Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, Department of Scientific Research, The Metropolitan Museum of Art, New York, NY 10028, Century Darkroom, Toronto, ON M4M 2S1, Canada, Colorado State University, University of Waterloo, Southern Connecticut State University, Clemson University, Oak Ridge National Laboratory, University of Bordeaux, BYU REU Program, New Mexico State University, Arizona State University, Biodesign Institute, Center for Applied Structural Discovery, University of Utah, University of Hawaii, Johns Hopkins University, Embry-Riddle Aeronautical University, Arizona State University, Utah State University, Department of Physics, United States Air Force Academy, Department of Chemistry, Case Western Reserve University, Air Force Research Laboratory, Wright-Patterson Air Force Base, United States Air Force Academy, Lousiana State University, Brigham Young University - Provo, The University of New Mexico, Department of Physics and Astronomy, Brigham Young University, SLAC National Accelerator Laboratory, Department of Chemistry, Brigham Young University, Department of Materials, Devices, and Energy Technologies, Sandia National Laboratories, Albuquerque, New Mexico 87185, USA, Department of Physics, New Mexico State University, Las Cruces, New Mexico 88003, USA, Center for Memory and Recording research, UCSD, Advanced Photon Source, Argonne National Laboratory, University of New Mexico, Los Alamos National Laboratory, University of Chicago

  • John Spence

    Brigham Young University, Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, Department of Scientific Research, The Metropolitan Museum of Art, New York, NY 10028, Century Darkroom, Toronto, ON M4M 2S1, Canada, Colorado State University, University of Waterloo, Southern Connecticut State University, Clemson University, Oak Ridge National Laboratory, University of Bordeaux, BYU REU Program, New Mexico State University, Arizona State University, Biodesign Institute, Center for Applied Structural Discovery, University of Utah, University of Hawaii, Johns Hopkins University, Embry-Riddle Aeronautical University, Arizona State University, Utah State University, Department of Physics, United States Air Force Academy, Department of Chemistry, Case Western Reserve University, Air Force Research Laboratory, Wright-Patterson Air Force Base, United States Air Force Academy, Lousiana State University, Brigham Young University - Provo, The University of New Mexico, Department of Physics and Astronomy, Brigham Young University, SLAC National Accelerator Laboratory, Department of Chemistry, Brigham Young University, Department of Materials, Devices, and Energy Technologies, Sandia National Laboratories, Albuquerque, New Mexico 87185, USA, Department of Physics, New Mexico State University, Las Cruces, New Mexico 88003, USA, Center for Memory and Recording research, UCSD, Advanced Photon Source, Argonne National Laboratory, University of New Mexico, Los Alamos National Laboratory, University of Chicago

  • John Spence

    Brigham Young University, Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, Department of Scientific Research, The Metropolitan Museum of Art, New York, NY 10028, Century Darkroom, Toronto, ON M4M 2S1, Canada, Colorado State University, University of Waterloo, Southern Connecticut State University, Clemson University, Oak Ridge National Laboratory, University of Bordeaux, BYU REU Program, New Mexico State University, Arizona State University, Biodesign Institute, Center for Applied Structural Discovery, University of Utah, University of Hawaii, Johns Hopkins University, Embry-Riddle Aeronautical University, Arizona State University, Utah State University, Department of Physics, United States Air Force Academy, Department of Chemistry, Case Western Reserve University, Air Force Research Laboratory, Wright-Patterson Air Force Base, United States Air Force Academy, Lousiana State University, Brigham Young University - Provo, The University of New Mexico, Department of Physics and Astronomy, Brigham Young University, SLAC National Accelerator Laboratory, Department of Chemistry, Brigham Young University, Department of Materials, Devices, and Energy Technologies, Sandia National Laboratories, Albuquerque, New Mexico 87185, USA, Department of Physics, New Mexico State University, Las Cruces, New Mexico 88003, USA, Center for Memory and Recording research, UCSD, Advanced Photon Source, Argonne National Laboratory, University of New Mexico, Los Alamos National Laboratory, University of Chicago

  • John Spence

    Brigham Young University, Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, Department of Scientific Research, The Metropolitan Museum of Art, New York, NY 10028, Century Darkroom, Toronto, ON M4M 2S1, Canada, Colorado State University, University of Waterloo, Southern Connecticut State University, Clemson University, Oak Ridge National Laboratory, University of Bordeaux, BYU REU Program, New Mexico State University, Arizona State University, Biodesign Institute, Center for Applied Structural Discovery, University of Utah, University of Hawaii, Johns Hopkins University, Embry-Riddle Aeronautical University, Arizona State University, Utah State University, Department of Physics, United States Air Force Academy, Department of Chemistry, Case Western Reserve University, Air Force Research Laboratory, Wright-Patterson Air Force Base, United States Air Force Academy, Lousiana State University, Brigham Young University - Provo, The University of New Mexico, Department of Physics and Astronomy, Brigham Young University, SLAC National Accelerator Laboratory, Department of Chemistry, Brigham Young University, Department of Materials, Devices, and Energy Technologies, Sandia National Laboratories, Albuquerque, New Mexico 87185, USA, Department of Physics, New Mexico State University, Las Cruces, New Mexico 88003, USA, Center for Memory and Recording research, UCSD, Advanced Photon Source, Argonne National Laboratory, University of New Mexico, Los Alamos National Laboratory, University of Chicago

  • John Spence

    Brigham Young University, Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, Department of Scientific Research, The Metropolitan Museum of Art, New York, NY 10028, Century Darkroom, Toronto, ON M4M 2S1, Canada, Colorado State University, University of Waterloo, Southern Connecticut State University, Clemson University, Oak Ridge National Laboratory, University of Bordeaux, BYU REU Program, New Mexico State University, Arizona State University, Biodesign Institute, Center for Applied Structural Discovery, University of Utah, University of Hawaii, Johns Hopkins University, Embry-Riddle Aeronautical University, Arizona State University, Utah State University, Department of Physics, United States Air Force Academy, Department of Chemistry, Case Western Reserve University, Air Force Research Laboratory, Wright-Patterson Air Force Base, United States Air Force Academy, Lousiana State University, Brigham Young University - Provo, The University of New Mexico, Department of Physics and Astronomy, Brigham Young University, SLAC National Accelerator Laboratory, Department of Chemistry, Brigham Young University, Department of Materials, Devices, and Energy Technologies, Sandia National Laboratories, Albuquerque, New Mexico 87185, USA, Department of Physics, New Mexico State University, Las Cruces, New Mexico 88003, USA, Center for Memory and Recording research, UCSD, Advanced Photon Source, Argonne National Laboratory, University of New Mexico, Los Alamos National Laboratory, University of Chicago